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Saturday, July 18, 2020 | History

3 edition of Platelets and megakaryocytes. found in the catalog.

Platelets and megakaryocytes.

Platelets and megakaryocytes.

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Published by Humana Press in Totowa, NJ .
Written in English


Edition Notes

Statementedited by Jonathan M. Gibbins, Martyn P. Mahaut-Smith.
Classifications
LC ClassificationsQP
The Physical Object
Paginationxix, 385 p. :
Number of Pages385
ID Numbers
Open LibraryOL22593810M
ISBN 101588291014

Platelets are formed and released into the bloodstream by precursor cells called megakaryocytes that reside within the bone marrow. The production of platelets by megakaryocytes requires an intricate series of remodeling events that result in the release of thousands of platelets from a single megakaryocyte. Abnormalities in this process can result in clinically significant disorders.   Megakaryocytes are smaller in fetuses and infants and show less nuclear segmentation when compared to older children Platelet production appears to be dependent on megakaryocyte ploidy Platelet production rate under homeostatic conditions: 2 - 4 x 10 9 /kg/day; may increase 8 - 10x if needed; 10 day survival time in peripheral blood.

Platelets and Megakaryocytes, Volume 1: Functional Assays, edited by Jonathan M. No part of this book may be reproduced, stored in a retrieval system, or transmitted in. All journal articles featured in Platelets vol 31 issue 5. Accept. We use cookies to improve your website experience. To learn about our use of cookies and how you can manage your cookie settings, please see our Cookie Policy. By closing this message, you are consenting to our use of cookies.

  Circulating blood platelets are specialized cells that prevent bleeding and minimize blood vessel injury. Large progenitor cells in the bone marrow called megakaryocytes (MKs) are the source of platelets. MKs release platelets through a series of fascinating cell biological events. platelet: A small, colorless, disc-shaped particle found in the blood of mammals. It plays an important role in the formation of blood clots. Platelets, also called thrombocytes, are membrane-bound cell fragments derived from the fragmentation of larger precursor cells called megakaryocytes, which are derived from stem cells in the bone marrow.


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Platelets and megakaryocytes Download PDF EPUB FB2

In Platelets and Megakaryocytes, Volume 2: Perspectives and Techniques leading expert researchers-many responsible for seminal discoveries in the field-offer basic and advanced techniques for studying cell signaling in the regulation and function of platelets and megakaryocytes, as well as state-of-the-art commentaries on our understanding of these : Hardcover.

A companion volume, Platelets and Megakaryocytes, Volume 2: Perspectives and Techniques offers a state-of-the-art survey of our understanding of these cells, with emphasis on the role of cell signaling in their regulation and function, as well as the use of molecular and post-genomic techniques for their : $ A companion volume, Platelets and Megakaryocytes, Volume 2: Perspectives and Techniques offers a state-of-the-art survey of our understanding of these cells, with emphasis on the role of cell signaling in their regulation and function, as well as the use of molecular and post-genomic techniques for their study.

Authoritative and up-to-date, Platelets and Megakaryocytes: Volume 4, Additional Protocols and Perspectives adds a wealth of new expertise for the labs of scientists working in this key biological area of study. This comprehensive volume covers techniques for the study of platelet function, approaches for investigating megakaryocyte function, and perspectives on important overall concepts in the field of megakaryocyte and platelet biology.

For both volumes: A comprehensive collection of cutting-edge methods for the molecular and cellular analysis of platelets and megakaryocytes. Volume 1 details basic and advanced techniques for. This book opens with a developmentally oriented chapter by Janine Breton-Gorius on megakaryocyte maturation and platelet release in normal conditions, which serves to set the scene Reviews: 1.

Platelets are released from megakaryocytes (MKs) through several steps, beginning with stem cells. Stem cells differentiate into immature MKs and further into mature MKs with unique features, such as a large size and polyploidism.

Finally, mature MKs release platelets. Megakaryocytes were found in the microvasculature of the heart in all cases, in glomeruli, and in increased numbers in the lungs. Bone marrow megakaryocytes were mildly increased in number with morphologic features indicating active platelet production, and contained virions as identified on electron microscopy (Supplemental Figure 2).

In contrast, mice with a normal platelet count but impaired platelet function due to abnormal platelet granules, such as the muted, mocha, or cocoa mouse, have bleeding times prolonged up to fold,29 Second, both megakaryocytes and platelets from mutant mice display an ultrastructural morphology similar to that of cells from normal animals.

Thus, the main aim of Platelets and Megakaryocytes: Volume 3, Additional Protocols and Perspectives is to complement the first two volumes published in. Thus, the main aim of Platelets and Megakaryocytes: Volume 3, Additional Prools and Perspectives is to complement the first two volumes published in by adding recently developed state of.

Megakaryocytes, Platelets, Macrophages, and Eosinophils by J. Robin Harris Megakaryocytes, Platelets, Macrophages, and Eosinophils | Blood Cell Biochemistry was initially conceived as part of the Plenum series Subcellular Biochemistry, from which it has developed into a separate series.

In Platelets and Megakaryocytes, Volume 2: Perspectives and Techniques leading expert researchers-many responsible for seminal discoveries in the field-offer basic and advanced techniques for studying cell signaling in the regulation and function of platelets and megakaryocytes, as well as state-of-the-art commentaries on our understanding of.

Buy Platelets and Megakaryocytes (): Volume 3, Additional Protocols and Perspectives: NHBS - Edited By: Jonathan M Gibbins and Martyn P Mahaut-Smith, Humana Press About Help Blog Jobs Established NHBS GmbH Covid Comprehensive and definitive source of knowledge about platelets for clinicians, pathologists and scientists.

Integrates the entire field of platelet biology, pathophysiology, and clinical medicine. Full color reference comprising 64 chapters, pages, references. Contributions from world leaders in their fields. Comprehensive and cutting-edge, the two volumes of Platelets and Megakaryocytes offer novice and experienced cell biologists, hematologists, and clinicians not only a benchmark survey of the field, but also a comprehensive library of proven techniques essential for productive research on platelets and megakaryocytes : Hardcover.

The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte.

It consists of five s- tions split between two volumes. Description: This book, one of two volumes providing protocols for working with Price: $   The ability of platelets to take up foreign particulates from plasma and transfer them to apparently intact alpha granules was reported several years ago.

60 Recently, megakaryocytes have been shown to take up transfused horseradish peroxidase into alpha granules and the organelles can be detected subsequently in circulating platelets by. The fact that platelets are more numerous in arterial than mixed venous blood whereas the converse applies for megakaryocytes suggests that many platelets are first released from megakaryocytes trapped in the lungs, – but this does not mean that the lungs are the principal site of platelet production.

Megakaryocytes are particularly easy to find in pulmonary capillaries when there is an increased. The platelet is a circulating anuclear fragment of a bone marrow megakaryocyte, 3 to 4 μm in diameter, with limited synthetic capability.

The mean normal platelet count is betweenandcells/mm3, although there is a wide range of accepted normal values in most laboratories that extend as low asto as high as ,/mm3.Qualitative defects of platelets and megakaryocytes (MKs) give rise to mucocutaneous bleeding through a modified platelet function and/or production [1,2].

There is widespread clinical variability. These inherited diseases are significant, for as well as providing a better understanding of the molecular.Book Review: Platelets and Megakaryocytes, vol.

1: Functional Assays. M. K. Boudreaux. Veterinary Pathology 2, Download Citation. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click on.